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However, heterogeneous outcomes have been observed when it comes to T cell infiltration, suggesting a different potential profit after ICI therapies. It has been proposed that neoAg-specific T cells play a distinguished function in ICI efficacy, since TMB correlates with the response fee to these therapies . Analyses of expression of mutated sequences revealed that about 65% of mutations had been located at expressed genes. A high variability concerning expression of mutated genes with potential neoAg-coding capacity has been reported in TNBC, starting from 35-50% in some instances , to more than 80% in others . The pattern size and the filtering standards used to outline expression within the completely different studies may account for these discrepancies, in addition to for the variations with our outcomes. By using these mutations, we predicted HLA class I-restricted potential neoAgs encoded by mutated genes, observing a median of ninety eight neoAgs.
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